2015/16 Publications

Between 1st April 2015 - 31st March 2016, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).

April - June 2015

"Virtual" (Computed) Fractional Flow Reserve. Current Challenges and Limitations (Cardiology)

Response of bone turnover markers to three oral bisphosphonate therapies in postmenopausal osteoporosis: the TRIO study (Metabolic Bone)

Cognitive behavioural therapy vs standardised medical care for adults with Dissociative non-Epileptic Seizures (CODES): a multicentre randomised controlled trial protocol (Epilepsy, Neurology)

Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate-length CAG repeat expansions in Ataxin-2 does not have 1C2-positive polyglutamine inclusions (Motor Neurone Disease, Neurology)

Osteoprotegerin in cardiometabolic disorders (Cardiology)

Prednisolone or pentoxifylline for alcoholic hepatitis (Hepatitis, Hepatology)

Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood (Metabolic bone)

Elevated plasma CXCL12α is associated with a poorer prognosis in pulmonary arterial hypertension (Pulmonary Hypertension)

C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis (Neurology)

The Spectrum of C9orf72-mediated Neurodegeneration and Amyotrophic Lateral Sclerosis (Neurology)

July - September 2015

Survivorship and Improving Quality of Life in Men with Prostate Cancer (Prostate Cancer)

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK) (Respiratory medicine)

Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height (Obstetrics)

Towards diagnostic conversational profiles of patients presenting with dementia or functional memory disorders to memory clinics (Dementia, Neurology)

Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy (Neurology)

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial (Diabetes, Endocrinology)

Multicentre randomized controlled trial of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker withdrawal in advanced renal disease: the STOP-ACEi trial (Nephrology)

Phase III study of pasireotide long-acting release in patients with metastatic neuroendocrine tumors and carcinoid symptoms refractory to available somatostatin analogues (Endocrinology)

Comparing the Effect of a Twice-weekly Tacrolimus and Betamethasone Valerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis (Dermatitis)

Evaluation of adipocytokines and traditional cardiometabolic risk factors in young male cancer survivors: an age-matched control study (Cardiology)

Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection (HIV Infection)

Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis (DiPALS): a multicentre, open-label, randomised controlled trial (Neurology)

October - December 2015

Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk (Cardiology)

Outcomes after thrombus aspiration for ST elevation myocardial infarction: 1-year follow-up of the prospective randomised TOTAL trial (Cardiology)

The clinical effectiveness and cost-effectiveness of STeroids Or Pentoxifylline for Alcoholic Hepatitis (STOPAH): a 2 × 2 factorial randomised controlled trial (Alcoholic hepatitis)

Anatomical substrates and neurocognitive predictors of daily numerical abilities in mild cognitive impairment. (Neurology)

Journeying through Dementia, a community-based self-management intervention for people aged 65 years and over: a feasibility study to inform a future trial (Dementia)

Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery (Cardiology)

A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery (Cardiology)

Developing family-centred care in a neonatal intensive care unit: an action research study protocol. (Neonatology)

Cognitive impairment in adults with epilepsy: The relationship between subjective and objective assessments of cognition (Epilepsy)

Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model (Vascular medicine)

Hypothermia for Intracranial Hypertension after Traumatic Brain Injury (Traumatic Brain Injury)

Patient Acceptability of the Yorkshire Dialysis Decision Aid (YoDDA) Booklet: A Prospective Non-Randomized Comparison Study Across 6 Predialysis Services (Renal Dialysis)

Longitudinal bioimpedance vector plots add little value to fluid management of peritoneal dialysis patients (Renal Dialysis)

Accuracy of Continuous Glucose Monitoring During Three Closed-Loop Home Studies Under Free-Living Conditions (Diabetes)

Sedation and analgesia practices in neonatal intensive care units (EUROPAIN): results from a prospective cohort study (Neonatal Intensive care)

Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial (Obstetrics)

A brief conversation analytic communication intervention can change history-taking in the seizure clinic (Epilepsy)

January - March 2016

Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial (Optic Neuritis)

Platelet Inhibition With Ticagrelor 60 mg Versus 90 mg Twice Daily in the PEGASUS-TIMI 54 Trial (Cardiology)

Renal artery sympathetic denervation: observations from the UK experience (Renal)

Optic Perineuritis (Optic neuritis)

Identifying metabolite markers for preterm birth in cervicovaginal fluid by magnetic resonance spectroscopy (Obstetrics)

High prevalence of cardiovascular and respiratory abnormalities in advanced, intensively treated (transplanted) myeloma: The case for 'late effects' screening and preventive strategies (Myeloma)

Eligibility for clinical trials in primary Sjögren's syndrome: lessons from the UK Primary Sjögren's Syndrome Registry (Sjögren's Syndrome)

A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome (Sjögren's Syndrome)

Conversational assessment in memory clinic encounters: interactional profiling for differentiating dementia from functional memory disorders (Dementia)

SaFaRI: sacral nerve stimulation versus the FENIX magnetic sphincter augmentation for adult faecal incontinence: a randomised investigation (General Surgery)