2017/18 Publications

Between 1st April 2017 - 31st March 2018, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).

The TiM system: developing a novel telehealth service to improve access to specialist care in motor neurone disease using user-centered design (Telehealth in Motor Neurone Disease study)

B-cell activity markers are associated with different disease activity domains in primary Sjögren's syndrome (UKPSSR study)

The DiPEP (Diagnosis of PE in Pregnancy) biomarker study: An observational cohort study augmented with additional cases to determine the diagnostic utility of biomarkers for suspected venous thromboembolism during pregnancy and puerperium (DiPEP study)

Patient-completed, preoperative web-based anaesthetic assessment questionnaire (electronic Personal Assessment Questionnaire PreOperative): Development and validation (EPAQ Study)

Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS Study)

Impact of food, alcohol and pH on modified-release hydrocortisone developed to treat congenital adrenal hyperplasia (DIUR study)

Fast-Acting Insulin Aspart Improves Glycemic Control in Basal-Bolus Treatment for Type 1 Diabetes: Results of a 26-Week Multicenter, Active-Controlled, Treat-to-Target, Randomized, Parallel-Group Trial (Onset 1)

Cardiac Autonomic Regulation and Repolarization During Acute Experimental Hypoglycemia in Type 2 Diabetes

Diurnal Differences in Risk of Cardiac Arrhythmias During Spontaneous Hypoglycemia in Young People With Type 1 Diabetes

Relationship of glycated haemoglobin and reported hypoglycaemia to cardiovascular outcomes in patients with type 2 diabetes and recent acute coronary syndrome events: The EXAMINE trial

AHEAD Study: an observational study of the management of anticoagulated patients who suffer head injury

Change in diagnostic confidence brought about by using in utero MRI for fetal structural brain pathology: analysis of the MERIDIAN cohort (Meridian Study)

Anatomical subgroup analysis of the MERIDIAN cohort: Ventriculomegaly (Meridian Study)

Association of Coloproctology of Great Britain and Ireland Consensus Exercise on Surgical Management of Fistulating Perianal Crohn's Disease (ENiGMA Study)

International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis (DOPPS Study)

Job retention vocational rehabilitation for employed people with inflammatory arthritis (WORK-IA): a feasibility randomized controlled trial

Association between maternal sleep practices and late stillbirth - findings from a stillbirth case-control study (MiNESS Study)

Cost-Effectiveness of Long-Term Ticagrelor in Patients With Prior Myocardial Infarction: Results From the PEGASUS-TIMI 54 Trial (PEGASUS Study)

Efficacy and Safety of Ticagrelor Over Time in Patients With Prior MI in PEGASUS-TIMI 54 (PEGASUS Study)

Impact of presentation and transfer delays on complete ST-segment resolution before primary percutaneous coronary intervention: insights from the ATLANTIC trial (ATLANTIC Study)

Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention: A subanalysis of the ATLANTIC Trial (ATLANTIC Study)

Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis: Results From the VIRTU-Fast Study (VIRTU Study)

Pharmacokinetics, safety and efficacy of a recombinant factor IX product, trenonacog alfa in previously treated haemophilia B patients (IB1001 in Haemophilia)

Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial (BEEP Study)

Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations (PINS study)

Surgery for constipation: systematic review and practice recommendations: Results II: Hitching procedures for the rectum (rectal suspension) (CAPACITY 1, CAPACITY 2, CAPACITY 3 Studies)

Surgery for constipation: systematic review and clinical guidance: Paper 1: Introduction & Methods (CAPACITY 1, CAPACITY 2, CAPACITY 3 Studies)

Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial (PROBESE Study)

Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients (BISTRO Study)

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling (PAH Biobank)

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension (PAH COHORT Study)

Radical cystectomy (bladder removal) against intravesical BCG immunotherapy for high-risk non-muscle invasive bladder cancer (BRAVO): a protocol for a randomised controlled feasibility study (BRAVO Study)

An evaluation of the effect of an angiotensin-converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: a randomized placebo-controlled trial (AARDVARK Study)

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial (ARREST Study)

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease (CANTOS Study)

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial (CANTOS Study)

Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial (CANTOS Study)

Cost-effectiveness of blinatumomab versus salvage chemotherapy in relapsed or refractory Philadelphia-chromosome-negative B-precursor acute lymphoblastic leukemia from a US payer perspective (TOWER Study)

Recurrent serious infections in patients with rheumatoid arthritis-results from the British Society for Rheumatology Biologics Register (BSRBR-RA Study)

Campath, calcineurin inhibitor reduction, and chronic allograft nephropathy (the 3C Study) - results of a randomized controlled clinical trial (3C Study)

Evaluating the effectiveness of IV iron dosing for anemia management in common clinical practice: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS Study)

Mortality risk in patients on hemodiafiltration versus hemodialysis: a 'real-world' comparison from the DOPPS. (DOPPS Study)

International Differences in the Location and Use of Arteriovenous Accesses Created for Hemodialysis: Results From the Dialysis Outcomes and Practice Patterns Study (DOPPS Study)

Unique hemoglobin A1c level distribution and its relationship with mortality in diabetic hemodialysis patients. (DOPPS Study)

Hemodialysis practice patterns in the Russia Dialysis Outcomes and Practice Patterns Study (DOPPS), with international comparisons. (DOPPS Study)

Initiation of Sevelamer and Mortality among Hemodialysis Patients Treated with Calcium-Based Phosphate Binders. (DOPPS Study)

The Dialysis Outcomes and Practice Patterns Study (DOPPS) in Turkey. (DOPPS Study)

Coping with kidney disease - qualitative findings from the Empowering Patients on Choices for Renal Replacement Therapy (EPOCH-RRT) study. (DOPPS Study)

Understanding associations of hemodialysis practices with clinical and patient-reported outcomes: examples from the DOPPS. (DOPPS Study)

Diagnostic Accuracy of Biomarkers and Imaging for Bone Turnover in Renal Osteodystrophy (Biomarkers and imaging techniques Study)

British Isles Lupus Assessment Group Biologics Register. Short-term efficacy and safety of rituximab therapy in refractory systemic lupus erythematosus: results from the British Isles Lupus Assessment Group Biologics Register. (BILAG Study)

Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study (ESOS Study)

Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study. (ESOS Study)

Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sjögren's syndrome: examination of data from the UK Primary Sjögren's Syndrome Registry. (UKPSSR Study)

Magnetic induction spectroscopy (MIS)-probe design for cervical tissue measurements.

MERIT study investigators. Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study. (MERIT-1 Study)

COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non-Epileptic Seizures (CODES): statistical and economic analysis plan for a randomised controlled trial. (CODES Study)

Translational approaches to restoring mitochondrial function in Parkinson's disease. (Mitochondrial biomarkers in Parkinson’s Study)

Spontaneous Preterm Birth Is Associated with Differential Expression of Vaginal Metabolites by Lactobacilli-Dominated Microflora. (ECCLIPPX-spectroscopy of the cervix Study)

Mid-gestational changes in cervicovaginal fluid cytokine levels in asymptomatic pregnant women are predictive markers of inflammation-associated spontaneous preterm birth (ECCLIPPX-spectroscopy of the cervix Study)

Impact of pelvic floor muscle training on sexual function of women with urinary incontinence and a comparison of electrical stimulation versus standard treatment (IPSU trial): a randomised controlled trial. (IPSU Study)

Effects of discontinuing oral bisphosphonate treatments for postmenopausal osteoporosis on bone turnover markers and bone density. (Effect of Bisphosphonates on Bone Study)

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling. (Bridge Study)