2018/19 Publications

Between 1st April 2018 - 31st March 2019, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).

Accident and Emergency

Understanding the management of patients with head injury taking warfarin: who should we scan and when? Lessons from the AHEAD study (15705: The AHEAD Study)

Consensus-derived clinical decision rules to guide advanced imaging decisions for pulmonary embolism in pregnancy and the postpartum period (STH17334: DiPEP)

Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: the DiPEP diagnostic study with decision-analysis modelling (STH17334: DiPEP)

The DiPEP study: an observational study of the diagnostic accuracy of clinical assessment, D-dimer and chest x-ray for suspected pulmonary embolism in pregnancy and postpartum (STH17334: DiPEP)

Development and prospective external validation of a tool to predict poor recovery at 9 months after acute ankle sprain in UK emergency departments: the SPRAINED prognostic model (18298: SPRAINED)


Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation (STH15268: The Amaze Trial)

Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction: ATLANTIC-Morphine (STH16126: The ATLANTIC Study)

Pre-hospital administration of ticagrelor in diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A sub-analysis of the ATLANTIC trial (STH16126: The ATLANTIC Study)

Study of Two Dose Regimens of Ticagrelor Compared with Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention for Stable Coronary Artery Disease (STEEL-PCI) (STH18423: STEEL PCI)

Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome (STH19177: WILLOW - ACS)

Pharmacodynamic Effects of a 6-Hour Regimen of Enoxaparin in Patients Undergoing Primary Percutaneous Coronary Intervention (PENNY PCI Study) (19752: PENNY PCI)


Allergy Alert Test for p-Phenylenediamine-Allergic Hair Dye Users (STH16486: Proof of Concept Allergy Alert Test)

Diabetes and Endocrinology

A prospective longitudinal study of Pasireotide in Nelson's syndrome (STH15164: SOM230 in Nelson's Syndrome)

Sustained Reduction in Severe Hypoglycemia in Adults With Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia: Two-Year Follow-up in the HypoCOMPaSS Randomized Clinical Trial (15582: HYPOCOMPASS)

Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans (18300: Hypoglycaemia)

Prolonged Prothrombotic Effects of Antecedent Hypoglycemia in Individuals With Type 2 Diabetes (18300: Hypoglycaemia)

Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial. (STH18976: OPTION-DM)

Effect of once-weekly semaglutide on the counterregulatory response to hypoglycaemia in people with type 2 diabetes: A randomized, placebo-controlled, double-blind, crossover trial (19509: PIONEER-5)

Salbutamol‐induced electrophysiological changes show no correlation with electrophysiological changes during hyperinsulinaemic–hypoglycaemic clamp in young people with Type 1 diabetes (STH20048: Impaired Awareness of Hypoglycemia (IAH))


Autologous haematopoietic stem cell transplantation (aHSCT) for severe resistant autoimmune and inflammatory diseases - a guide for the generalist (STH19579: ASTIC-LITE)

Immune Reconstitution After Autologous Hematopoietic Stem Cell Transplantation in Crohn’s Disease: Current Status and Future Directions. A Review on Behalf of the EBMT Autoimmune Diseases Working Party and the Autologous Stem Cell Transplantation In Refractory CD—Low Intensity Therapy Evaluation Study Investigators (STH19579: ASTIC-LITE)

Follow-on RifAximin for the Prevention of recurrence following standard treatment of Infection with Clostridium Difficile (RAPID): a randomised placebo controlled trial (STH17047: RAPID)


Autologous Haematopoietic Stem Cell Transplantation in Multiple Sclerosis: a Review of Current Literature and Future Directions for Transplant Haematologists and Oncologists (STH14073: ANT)

Once-weekly prophylaxis with glycoPEGylated recombinant factor VIII (N8-GP) in severe haemophilia A: Safety and efficacy results from pathfinder 2 (randomized phase III trial) (STH16367: Pathfinder 2)

Infectious Diseases

HIV gp120 in the Lungs of Antiretroviral Therapy-treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci (STH15411: HIV in S. pneumoniae infection)

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists (STH15949: Bacterial colonisation in COPD)

Medical Imaging and Medical Physics

Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models (STH18285: REPEATABILITY)

Metabolic Bone

The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA? (STH15691: Sheffield Musculoskeletal Biobank)


Initial experience of an investigational 3T MR scanner designed for use on neonatal wards (STH18584: FIREFLY)


Efficacy of the Head Up collar in facilitating functional head movements in patients with Amyotrophic Lateral Sclerosis (STH15573: Head Up)

Effect of Nonmyeloablative Hematopoietic Stem Cell Transplantation vs Continued Disease-Modifying Therapy on Disease Progression in Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Clinical Trial (STH16542: MIST)

Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study (STH17249: MS-SMART)

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease (STH18493: UP study)

A thorough characterisation of gait impairment in patients with Multiple Sclerosis (STH18829: MS SMART - ADD ON)

Reduced habit-driven errors in Parkinson’s Disease (STH20087: ATP correlation in PD)


Mid-gestational changes in cervicovaginal fluid cytokine levels in asymptomatic pregnant women are predictive markers of inflammation-associated spontaneous preterm birth (STH16102: ECCLIPPX)

Influence of Gestational Age at Initiation of Antihypertensive Therapy: Secondary Analysis of CHIPS Trial Data (Control of Hypertension in Pregnancy Study) (STH15660 CHIPS)

Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: Results from the MAVIDOS trial (15780: MAVIDOS)


Mortality risk in patients on hemodiafiltration versus hemodialysis: a 'real-world' comparison from the DOPPS (STH14183: DOPPS)

Diagnostic Accuracy of Biomarkers and Imaging for Bone Turnover in Renal Osteodystrophy (STH17141: Biomarkers and imaging techniques)

Intravenous Iron in Patients Undergoing Maintenance Hemodialysis (STH18111: PIVOTAL)

Effects of Sacubitril/Valsartan Versus Irbesartan in Patients with Chronic Kidney Disease: A Randomised Double-Blind Trial (STH18238: UK Heart and Renal Protection (HARP)-III)


Divergent Roles for TRAIL in Lung Diseases (STH16436: PAH Biobank)

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis (STH18400: Bridge)

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension (STH18400: Bridge)


Recurrent serious infections in patients with rheumatoid arthritis-results from the British Society for Rheumatology Biologics Register (STH14349: BSRBR-RA)

The effects of upper and lower limb exercise on the microvascular reactivity in limited cutaneous systemic sclerosis patients (STH19339 Exercise in patients with Systemic Sclerosis)


Overcoming difficulties with equipoise to enable recruitment to a randomised controlled trial of partial ablation vs radical prostatectomy for unilateral localised prostate cancer (STH18658: PART)

Partial ablation versus radical prostatectomy in intermediate-risk prostate cancer: the PART feasibility RCT (STH18658: PART)

Does the robot have a role in radical cystectomy? (STH19805: iROC)