2019/20 Publications

Between 1st April 2019 - 31st March 2020, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility.

Accident and Emergency

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial (STH17092: CRASH 3)


Cardiovascular

Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention: A subanalysis of the ATLANTIC Trial (STH16126: ATLANTIC)

Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes (STH20030: A multi-center, double-blind, randomized, placebo-controlled study to assess the pharmacodynamics, pharmacokinetics, tolerability, and safety of a single subcutaneous injection of ACT-246475 in adults with stable coronary artery disease)


Dermatology

Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2 (STH18454: Liberty AD SOLO)

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial (STH18627: BEEP)


Haematology

Fixed doses of N8-GP prophylaxis maintain moderate-to-mild factor VIII levels in the majority of patients with severe hemophilia A (STH16367: Pathfinder 2)

Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors: phase 2 trial results (STH19995: Explorer 4)


Infectious Diseases

ART in HIV-Positive Persons With Low Pretreatment Viremia: Results From the START Trial (STH15942: START)

Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy–Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial (STH15942: START)

Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison (STH15942: START)

Risk factors for antiretroviral therapy (ART) discontinuation in a large multinational trial of early ART initiators (STH15942: START)

Risk Factors for Low CD4+ Count Recovery Despite Viral Suppression Among Participants Initiating Antiretroviral Treatment With CD4+ Counts > 500 Cells/mm3: Findings From the Strategic Timing of AntiRetroviral Therapy (START) Trial (STH15942: START)

Role of Inflammatory Biomarkers in the Prevalence and Incidence of Hypertension Among HIV-Positive Participants in the START Trial (STH15942: START)

The benefit of immediate compared with deferred antiretroviral therapy on CD4+ cell count recovery in early HIV infection (STH15942: START)


Neurological

Serum FGF-21, GDF-15, and blood mtDNA copy number are not biomarkers of Parkinson disease (STH16350: Mitochondrial biomarkers in Parkinson’s)

Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in Alzheimer's disease (STH17001: Improving detection and prevention of cognitive decline in ageing)

Using telehealth in motor neuron disease to increase access to specialist multidisciplinary care: a UK-based pilot and feasibility study (STH17165: Telehealth in Motor Neurone Disease)

Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2) (STH18323: PISCES II)

Transcutaneous Auricular Vagus Nerve Stimulation with Upper Limb Repetitive Task Practice May Improve Sensory Recovery in Chronic Stroke (STH19008: Feasibility and Acceptability of Transcutaneous Vagal Nerve Stimulation in Recovery of Upper Limb function Post Stroke)

Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial (STH19012: LEVALS DEME4308)


Obstetrics

Postnatal pelvic floor muscle stiffness measured by vaginal elastometry in women with obstetric anal sphincter injury: a pilot study (STH18128: Pelvic floor dysfunction)


Orthopaedics

Platelet rich plasma injection for acute Achilles tendon rupture: PATH-2 randomised, placebo controlled, superiority trial (STH19542: PATH 2)


Renal Studies

Retraining for prevention of peritonitis in peritoneal dialysis patients: A randomized controlled trial (STH16431: Peritonitis Prevention Study (PEPS))


Respiratory Studies

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension (STH17049: PAH COHORT)

Germline selection shapes human mitochondrial DNA diversity (STH18400: NIHR BioResource Rare Diseases)

Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy – the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial (STH18188: EME-TIPAC)


Rheumatology Studies

Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis (STH17049: Beat Lupus)