2019/20 Publications

Accident and Emergency

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial (STH17092: CRASH 3)

Cardiovascular

Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention: A subanalysis of the ATLANTIC Trial (STH16126: ATLANTIC)

Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes (STH20030: A multi-center, double-blind, randomized, placebo-controlled study to assess the pharmacodynamics, pharmacokinetics, tolerability, and safety of a single subcutaneous injection of ACT-246475 in adults with stable coronary artery disease)

Dermatology

Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2 (STH18454: Liberty AD SOLO)

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial (STH18627: BEEP)

Haematology

Fixed doses of N8-GP prophylaxis maintain moderate-to-mild factor VIII levels in the majority of patients with severe hemophilia A (STH16367: Pathfinder 2)

Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors: phase 2 trial results (STH19995: Explorer 4)

Infectious Diseases

ART in HIV-Positive Persons With Low Pretreatment Viremia: Results From the START Trial (STH15942: START)

Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy–Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial (STH15942: START)

Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison (STH15942: START)

Risk factors for antiretroviral therapy (ART) discontinuation in a large multinational trial of early ART initiators (STH15942: START)

Risk Factors for Low CD4+ Count Recovery Despite Viral Suppression Among Participants Initiating Antiretroviral Treatment With CD4+ Counts > 500 Cells/mm3: Findings From the Strategic Timing of AntiRetroviral Therapy (START) Trial (STH15942: START)

Role of Inflammatory Biomarkers in the Prevalence and Incidence of Hypertension Among HIV-Positive Participants in the START Trial (STH15942: START)

The benefit of immediate compared with deferred antiretroviral therapy on CD4+ cell count recovery in early HIV infection (STH15942: START)

Neurological

Serum FGF-21, GDF-15, and blood mtDNA copy number are not biomarkers of Parkinson disease (STH16350: Mitochondrial biomarkers in Parkinson’s)

Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in Alzheimer's disease (STH17001: Improving detection and prevention of cognitive decline in ageing)

Using telehealth in motor neuron disease to increase access to specialist multidisciplinary care: a UK-based pilot and feasibility study (STH17165: Telehealth in Motor Neurone Disease)

Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2) (STH18323: PISCES II)

Transcutaneous Auricular Vagus Nerve Stimulation with Upper Limb Repetitive Task Practice May Improve Sensory Recovery in Chronic Stroke (STH19008: Feasibility and Acceptability of Transcutaneous Vagal Nerve Stimulation in Recovery of Upper Limb function Post Stroke)

Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial (STH19012: LEVALS DEME4308)

Obstetrics

Postnatal pelvic floor muscle stiffness measured by vaginal elastometry in women with obstetric anal sphincter injury: a pilot study (STH18128: Pelvic floor dysfunction)

Orthopaedics

Platelet rich plasma injection for acute Achilles tendon rupture: PATH-2 randomised, placebo controlled, superiority trial (STH19542: PATH 2)

Renal Services

Retraining for prevention of peritonitis in peritoneal dialysis patients: A randomized controlled trial (STH16431: Peritonitis Prevention Study (PEPS))

Respiratory

Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension (STH17049: PAH COHORT)

Germline selection shapes human mitochondrial DNA diversity (STH18400: NIHR BioResource Rare Diseases)

Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy – the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial (STH18188: EME-TIPAC)

Rheumatology

Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: a UK cohort study analysis (STH17049: Beat Lupus)