2022/23 Publications

Between 1st April 2022 - 31st March 2023, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).

Accident and Emergency

Accuracy of emergency medical service telephone triage of need for an ambulance response in suspected COVID-19: an observational cohort study (STH16228: PRIEST)

Presentation cardiac troponin and early computed tomography coronary angiography in patients with suspected acute coronary syndrome: a pre-specified secondary analysis of the RAPID-CTCA trial (STH18377: RAPID CTCA)


Influence of body weight and body mass index on the chronic pharmacokinetic and pharmacodynamic responses to clinically available doses of ticagrelor in patients with chronic coronary syndromes (STH15908: PEGASUS)

Lipoprotein(a), cardiovascular events, and benefit of P2Y12 inhibition: insights from the PEGASUS-TIMI 54 trial (STH15908: PEGASUS)

Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54 (STH15908: PEGASUS)

Complete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction. Results From the COMPLETE Randomized Clinical Trial (STH18050: COMPLETE)

TCT-36 Complete Revascularization Versus Culprit Lesion–Only PCI in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease: A Subgroup Analysis of the COMPLETE Trial (STH18050: COMPLETE)

Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial (STH19388: IRONMAN)

Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial (STH19671: RIPCORD2)

Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial (STH19837: LIBERATES)

Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry (STH21180: NSTEMI Registry)

Presentation, care, and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology (STH21180: NSTEMI Registry)

Clinical Immunology

Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice (STH21919: ALABAMA)

Critical Care, Anaesthesia & Operating Services

Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (STH18220: ISARIC)

Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study (STH18220: ISARIC)

Diabetes and Endocrinology

Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial (STH18976: OPTION-DM)

Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT (STH18976: OPTION-DM)

Who really benefits from drug combinations and long titrations for pain? – Authors' reply (STH18976: OPTION-DM)

A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial - implications for therapeutic immune modulation (STH21519: ARCADIA)


A pilot study to evaluate changes in pelvic floor muscle tone following pelvic organ prolapse surgery using a novel intra-vaginal pressure sensor device (STH20182: IVPSD)


Fixed-Duration Ibrutinib-Venetoclax in Patients with Chronic Lymphocytic Leukemia and Comorbidities (STH20256: GLOW)

Infectious Diseases

Clonal population expansion of Staphylococcus aureus occurs due to escape from a finite number of intraphagocyte niches (STH14625: Macrophage responses to micro-organisms)

A randomized phase 3 trial of the immunogenicity and safety of coadministration of a live-attenuated tetravalent dengue vaccine (TAK-003) and an inactivated hepatitis a (HAV) virus vaccine in a dengue non-endemic country (STH20140: DEN 314)

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis (STH21355: RECOVERY)

Factors affecting turnaround time of SARS-CoV-2 sequencing for inpatient infection prevention and control decision making: analysis of data from the COG-UK HOCI study (STH21374: COG-UK HOCI)

An exploratory analysis of the response to ChAdOx1 nCoV-19 (AZD1222) vaccine in males and females (STH21413: COV002)

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (STH21439: PHOSP-COVID)

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (STH21439: PHOSP-COVID)

Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens (STH21520: PITCH)

Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial (STH21570: ENSEMBLE-2)

Medical Imaging and Medical Physics

Semi-automatic thresholding of RV trabeculation improves repeatability and diagnostic value in suspected pulmonary hypertension (STH18285: REPEATABILITY)

Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction (STH18285: REPEATABILITY)

Metabolic Bone

The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification (STH15691: Sheffield Musculoskeletal Biobank)


Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS (STH19145: SOD1)

Rapid identification of human muscle disease with fibre optic Raman spectroscopy (STH19266: Raman)

Fatigue in multiple sclerosis: A UK MS-register based study (STH19939: MS Register)

RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer’s Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity (STH20325: Infection & Dementia)

Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial (STH20709: NOVA)

Renal Services

Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease (STH18263: STOP-ACEi)

Variation in Peritoneal Dialysis Time on Therapy by Country Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (18334: UK PDOPPS)


Imaging biomarkers of lung ventilation in interstitial lung disease from 129Xe and oxygen enhanced 1H MRI (STH19593: TRISTAN)

A randomised controlled trial of intrapleural balloon intercostal chest drains to prevent drain displacement (STH20726: BASIC)

Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial (STH21421: STOP-COVID19)


Comorbidities in the UK Primary Sjögren’s Syndrome Registry (STH15541: UKPSSR)

Successful stopping of biologic therapy for remission in children and young people with juvenile idiopathic arthritis (STH17340: BCRD & STH18373: BSPAR)