2022/23 Publications
Between 1st April 2022 - 31st March 2023, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).
Accident & Emergency
Accuracy of emergency medical service telephone triage of need for an ambulance response in suspected COVID-19: an observational cohort study (STH16228: PRIEST)
Presentation cardiac troponin and early computed tomography coronary angiography in patients with suspected acute coronary syndrome: a pre-specified secondary analysis of the RAPID-CTCA trial (STH18377: RAPID CTCA)
Cardiovascular
Lipoprotein(a), cardiovascular events, and benefit of P2Y12 inhibition: insights from the PEGASUS-TIMI 54 trial (STH15908: PEGASUS)
Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54 (STH15908: PEGASUS)
TCT-36 Complete Revascularization Versus Culprit Lesion–Only PCI in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease: A Subgroup Analysis of the COMPLETE Trial (STH18050: COMPLETE)
Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial (STH19671: RIPCORD2)
Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry (STH21180: NSTEMI Registry)
Presentation, care, and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology (STH21180: NSTEMI Registry)
Clinical Immunology
Critical Care, Anaesthesia & Operating Services
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (STH18220: ISARIC)
Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study (STH18220: ISARIC)
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (STH18220: ISARIC)
Diabetes & Endocrinology
Gynaecology
Endometrial scratch in women undergoing first-time IVF treatment: a systematic review and meta-analysis of randomized controlled trials (STH18142: endometrial scratch)
Shared decision-making during childbirth in maternity units: the VIP mixed-methods study (STH18641: VIP)
A pilot study to evaluate changes in pelvic floor muscle tone following pelvic organ prolapse surgery using a novel intra-vaginal pressure sensor device (STH20182: IVPSD)
Haematology
Long-term efficacy and safety of subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors (STH19995: Explorer 4)
Fixed-Duration Ibrutinib-Venetoclax in Patients with Chronic Lymphocytic Leukemia and Comorbidities (STH20256: GLOW)
Efficacy and Safety of Single-Agent Zandelisib Administered By Intermittent Dosing in Patients with Relapsed or Refractory (R/R) Follicular Lymphoma (FL): Final Results of the Tidal Phase 2 Study (20634: TIDAL Study - ME-401)
Infectious Diseases
Clonal population expansion of Staphylococcus aureus occurs due to escape from a finite number of intraphagocyte niches (STH14625: Macrophage responses to micro-organisms)
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis (STH21355: RECOVERY)
Factors affecting turnaround time of SARS-CoV-2 sequencing for inpatient infection prevention and control decision making: analysis of data from the COG-UK HOCI study (STH21374: COG-UK HOCI)
An exploratory analysis of the response to ChAdOx1 nCoV-19 (AZD1222) vaccine in males and females (STH21413: COV002)
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (STH21439: PHOSP-COVID)
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (STH21439: PHOSP-COVID)
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (STH21439: PHOSP-COVID)
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens (STH21520: PITCH)
A plain language summary of the Janssen COVID-19 vaccine effectiveness and safety as a single dose and with a booster (STH21570: ENSEMBLE-2)
Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial (STH21570: ENSEMBLE-2)
Medical Imaging & Medical Physics
Semi-automatic thresholding of RV trabeculation improves repeatability and diagnostic value in suspected pulmonary hypertension (STH18285: REPEATABILITY)
Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction (STH18285: REPEATABILITY)
Metabolic Bone
The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification (STH15691: Sheffield Musculoskeletal Biobank)
Neonatology
Neurological
Prevalence of depression in amyotrophic lateral sclerosis/motor neuron disease: multi-attribute ascertainment and trajectories over 30 months (STH16508:TONIC)
Autologous haematopoietic stem cell transplantation for immune-mediated neurological diseases: what, how, who and why? (STH16542: MIST)
Performance of the GAD-7 in adults with dissociative seizures (STH18295: CODES)
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS (STH19145: SOD1)
Rapid identification of human muscle disease with fibre optic Raman spectroscopy (STH19266: Raman)
Key demographics and psychological skills associated with adjustment to progressive Multiple Sclerosis early in the diagnosis (STH19549: Psychological Adjustment in Progressive Multiple Sclerosis (PAIPMS))
Non-negative matrix factorisation of Raman spectra finds common patterns relating to neuromuscular disease across differing equipment configurations, preclinical models and human tissue (STH19904: Novel electrical impedance spectroscopy for neurological disorders.)
Fatigue in multiple sclerosis: A UK MS-register based study (STH19939: MS Register)
Vagus nerve stimulation paired with rehabilitation for stroke: Implantation experience from the VNS-REHAB trial (STH20221: VNS-REHAB)
RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer’s Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity (STH20325: Infection & Dementia)
Obstetrics
Renal Services
Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease (STH18263: STOP-ACEi)
Variation in Peritoneal Dialysis Time on Therapy by Country Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (STH18334: UK PDOPPS)
The STAGED-PKD 2-Stage Adaptive Study With a Patient Enrichment Strategy and Treatment Effect Modeling for Improved Study Design Efficiency in Patients With ADPKD (STH20441: Staged-PKD (ADPKD))
Respiratory
Imaging biomarkers of lung ventilation in interstitial lung disease from 129Xe and oxygen enhanced 1H MRI (STH19593: TRISTAN)
A randomised controlled trial of intrapleural balloon intercostal chest drains to prevent drain displacement (STH20726: BASIC)
Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial (STH21421: STOP-COVID19)
Rheumatology
Comorbidities in the UK Primary Sjögren’s Syndrome Registry (STH15541: UKPSSR)
Successful stopping of biologic therapy for remission in children and young people with juvenile idiopathic arthritis (STH17340: BCRD & STH18373: BSPAR)