2022/23 Publications
Between 1st April 2022 - 31st March 2023, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).
Accident and Emergency
Accuracy of emergency medical service telephone triage of need for an ambulance response in suspected COVID-19: an observational cohort study (STH16228: PRIEST)
Presentation cardiac troponin and early computed tomography coronary angiography in patients with suspected acute coronary syndrome: a pre-specified secondary analysis of the RAPID-CTCA trial (STH18377: RAPID CTCA)
Cardiovascular
Lipoprotein(a), cardiovascular events, and benefit of P2Y12 inhibition: insights from the PEGASUS-TIMI 54 trial (STH15908: PEGASUS)
Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54 (STH15908: PEGASUS)
TCT-36 Complete Revascularization Versus Culprit Lesion–Only PCI in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease: A Subgroup Analysis of the COMPLETE Trial (STH18050: COMPLETE)
Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial (STH19671: RIPCORD2)
Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry (STH21180: NSTEMI Registry)
Presentation, care, and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology (STH21180: NSTEMI Registry)
Clinical Immunology
Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice (STH21919: ALABAMA)
Critical Care, Anaesthesia & Operating Services
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (STH18220: ISARIC)
Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study (STH18220: ISARIC)
Diabetes and Endocrinology
Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT (STH18976: OPTION-DM)
Who really benefits from drug combinations and long titrations for pain? – Authors' reply (STH18976: OPTION-DM)
Gynaecology
A pilot study to evaluate changes in pelvic floor muscle tone following pelvic organ prolapse surgery using a novel intra-vaginal pressure sensor device (STH20182: IVPSD)
Haematology
Fixed-Duration Ibrutinib-Venetoclax in Patients with Chronic Lymphocytic Leukemia and Comorbidities (STH20256: GLOW)
Infectious Diseases
Clonal population expansion of Staphylococcus aureus occurs due to escape from a finite number of intraphagocyte niches (STH14625: Macrophage responses to micro-organisms)
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis (STH21355: RECOVERY)
Factors affecting turnaround time of SARS-CoV-2 sequencing for inpatient infection prevention and control decision making: analysis of data from the COG-UK HOCI study (STH21374: COG-UK HOCI)
An exploratory analysis of the response to ChAdOx1 nCoV-19 (AZD1222) vaccine in males and females (STH21413: COV002)
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (STH21439: PHOSP-COVID)
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (STH21439: PHOSP-COVID)
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens (STH21520: PITCH)
Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial (STH21570: ENSEMBLE-2)
Medical Imaging and Medical Physics
Semi-automatic thresholding of RV trabeculation improves repeatability and diagnostic value in suspected pulmonary hypertension (STH18285: REPEATABILITY)
Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction (STH18285: REPEATABILITY)
Metabolic Bone
The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification (STH15691: Sheffield Musculoskeletal Biobank)
Neurological
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS (STH19145: SOD1)
Rapid identification of human muscle disease with fibre optic Raman spectroscopy (STH19266: Raman)
Fatigue in multiple sclerosis: A UK MS-register based study (STH19939: MS Register)
RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer’s Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity (STH20325: Infection & Dementia)
Renal Services
Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease (STH18263: STOP-ACEi)
Variation in Peritoneal Dialysis Time on Therapy by Country Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (18334: UK PDOPPS)
Respiratory
Imaging biomarkers of lung ventilation in interstitial lung disease from 129Xe and oxygen enhanced 1H MRI (STH19593: TRISTAN)
A randomised controlled trial of intrapleural balloon intercostal chest drains to prevent drain displacement (STH20726: BASIC)
Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial (STH21421: STOP-COVID19)
Rheumatology
Comorbidities in the UK Primary Sjögren’s Syndrome Registry (STH15541: UKPSSR)
Successful stopping of biologic therapy for remission in children and young people with juvenile idiopathic arthritis (STH17340: BCRD & STH18373: BSPAR)