2016/17 Publications

April - June 2016

The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin (Dermatology)

A functional mechanistic study of the effect of emollients on the structure and function of the skin barrier (Dermatology)

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort (Rheumatoid Arthritis)

Haemorrhoidal artery ligation versus rubber band ligation for the management of symptomatic second-degree and third-degree haemorrhoids (HubBLe): a multicentre, open-label, randomised controlled trial (General Surgery: Haemorrhoid)

MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension (Pulmonary Arterial Hypertension)

Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health (Obesity and Bone Health)

PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation (Obstetrics)

The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy(Diabetes)

Late-night salivary cortisol may be valuable for assessing treatment response in patients with Cushing's disease: 12-month, Phase III pasireotide study (Cushing's Disease)

Low-Blood Glucose Avoidance Training Improves Glycemic Variability in Adults With Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia: HypoCOMPaSS Trial (Diabetes)

Long-term Benefits of Intensive Glucose Control for Preventing End-Stage Kidney Disease: ADVANCE-ON (Diabetes)

Prandial Options to Advance Basal Insulin Glargine Therapy: Testing Lixisenatide Plus Basal Insulin Versus Insulin Glulisine Either as Basal-Plus or Basal-Bolus in Type 2 Diabetes: The GetGoal Duo-2 Trial (Diabetes)

July - September 2016

Factors affecting outcomes in patients reaching end-stage kidney disease worldwide: differences in access to renal replacement therapy, modality use, and haemodialysis practices  (Renal)

Diagnostic Biomarkers in Women With Suspected Preeclampsia in a Prospective Multicenter Study (obstetrics)

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD (COPD)

The effect of bisphosphonate treatment on osteoclast precursor cells in postmenopausal osteoporosis: The TRIO study (Metabolic Bone)

Healthy HIV-1-seropositive individuals have impaired alveolar immunity despite highly active antiretroviral therapy (HIV)

Evaluating a novel cervical orthosis, the Sheffield Support Snood, in patients with amyotrophic lateral sclerosis/motor neuron disease with neck weakness (Neuroscience) 

British Neurotoxin Network recommendations for managing cervical dystonia in patients with a poor response to botulinum toxin (Dystonia DNA Bank Study)

Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer (ROCkeTS Study)

October - December 2016

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis (Dermatitis)

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries (surgery - ISOS Study) 

Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial (Hab Select Study)

Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy (MAVIDOS Study)

Comparison of stapled haemorrhoidopexy with traditional excisional surgery for haemorrhoidal disease (eTHoS): a pragmatic, multicentre, randomised controlled trial (eTHoS Study)

The RAPID-CTCA trial (Rapid Assessment of Potential Ischaemic Heart Disease with CTCA) - a multicentre parallel-group randomised trial to compare early computerised tomography coronary angiography versus standard care in patients presenting with suspected or confirmed acute coronary syndrome: study protocol for a randomised controlled trial (Rapid CTCA Study)

Patients Awaiting Surgical Repair for Large Abdominal Aortic Aneurysms Can Exercise at Moderate to Hard Intensities with a Low Risk of Adverse Events (HIT AAA Study)

The Cost Implications of Less Tight Versus Tight Control of Hypertension in Pregnancy (CHIPS Study)

Cervicovaginal Fluid Acetate: A Metabolite Marker of Preterm Birth in Symptomatic Pregnant Women (ECCLIPPX Study)

January - March 2017

Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study (MERIDIAN study)

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension (PAH Biobank Study)

An Objective Functional Characterisation of Head Movement Impairment in Individuals with Neck Muscle Weakness Due to Amyotrophic Lateral Sclerosis (Head Up Study)

Padeliporfin vascular-targeted photodynamic therapy versus active surveillance in men with low-risk prostate cancer (CLIN1001 PCM301): an open-label, phase 3, randomised controlled trial (Tookad Study)

A randomised controlled trial to compare the safety, effectiveness and cost-effectiveness of doxycycline (200 mg/day) with that of oral prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid: the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) trial (Blister study)

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension (PAH Biobank study)