2020/21 Publications

Between 1st April 2020 - 31st March 2021, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).

Characterisation of 22445 patients attending UK emergency departments with suspected COVID-19 infection: Observational cohort study (STH16228: PRIEST)

Derivation and validation of a clinical severity score for acutely ill adults with suspected COVID-19: The PRIEST observational cohort study (STH16228: PRIEST)

Post-exertion oxygen saturation as a prognostic factor for adverse outcome in patients attending the emergency department with suspected COVID-19: a substudy of the PRIEST observational cohort study (STH16228: PRIEST)

Accuracy of PE rule-out strategies in pregnancy: secondary analysis of the DiPEP study prospective cohort (STH17334: DiPEP)

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial (STH18085: HALT-IT)

Controlled observational study and economic evaluation of the effect of city-centre night-time alcohol intoxication management services on the emergency care system compared with usual care (STH19210: EDARA)

Evaluating alcohol intoxication management services: the EDARA mixed-methods study (STH19210: EDARA)

Diagnostic accuracy of the magnetocardiograph for patients with suspected acute coronary syndrome (STH19368: MCG Study)

Preoperative intravenous iron to treat anaemia before major abdominal surgery (PREVENTT): a randomised, double-blind, controlled trial (STH17221: PREVENTT)

Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1): Multicenter, Early Feasibility Study (STH18907: TROPHY)

Novel loss of function mutation in NOTCH1 in a family with bicuspid aortic valve, ventricular septal defect, thoracic aortic aneurysm, and aortic valve stenosis (STH19626: BRAVE)

Prolonged enoxaparin therapy compared with standard-of-care antithrombotic therapy in opiate-treated patients undergoing primary percutaneous coronary intervention (STH19902: PENNYWISE)

Whole-genome sequencing of a sporadic primary immunodeficiency cohort (STH18558: Whole-genome sequencing of a sporadic primary immunodeficiency cohort)

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study (STH18220: ISARIC)

Features of 20133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study (STH18220: ISARIC)

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease (STH18220: ISARIC)

Genetic mechanisms of critical illness in COVID-19 (STH21104: GenOMICC)

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 - The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial (STH21369: REMAP-CAP)

Implementation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 (REMAP-COVID) trial in a US health system—lessons learned and recommendations (STH21369: REMAP-CAP)

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 (STH21369: REMAP-CAP)

Corticotroph tumor progression during long-term therapy with osilodrostat in a patient with persistent Cushing’s disease (STH18457: LINC 3)

Efficacy and safety of osilodrostat in patients with Cushing's disease (LINC 3): a multicentre phase III study with a double-blind, randomised withdrawal phase (STH18457: LINC 3)

Modified-Release Hydrocortisone in Congenital Adrenal Hyperplasia (STH18946: DIUR005)

Pharmacodynamic studies of nasal tetracosactide with salivary glucocorticoids for a noninvasive Short Synacthen Test (STH19270: NeSST2)

Turoctocog alfa pegol provides effective management for major and minor surgical procedures in patients across all age groups with severe haemophilia A: Full data set from the pathfinder 3 and 5 phase III trials (STH16366: Pathfinder 3)

Long-term safety and efficacy of N8-GP in previously treated adults and adolescents with hemophilia A: Final results from pathfinder2 (STH16367: Pathfinder 2)

Open-Label, phase 2 study of blinatumomab as second salvage therapy in adults with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma (STH19577: Blinatumomab in Aggressive B-Cell Non Hodgkin Lymphoma)

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Dexamethasone in Hospitalized Patients with Covid-19 (STH21355: RECOVERY)

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 (STH21355: RECOVERY)

Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

RECOVERY trial: the UK covid-19 study resetting expectations for clinical trials (STH21355: RECOVERY)

Clinical Experience with Use of Remdesivir in the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2: a Case Series (STH21358: GILEAD SEVERE)

Patients With Uncomplicated Coronavirus Disease 2019 (COVID-19) Have Long-Term Persistent Symptoms and Functional Impairment Similar to Patients with Severe COVID-19: A Cautionary Tale During a Global Pandemic (STH21358: GILEAD SEVERE)

Remdesivir for Severe Coronavirus Disease 2019 (COVID19) Versus a Cohort Receiving Standard of Care (STH21358: GILEAD SEVERE)

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 (STH21358: GILEAD SEVERE)

Antibody evasion by the P.1 strain of SARS-CoV-2 (STH21413: COV002)

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial (STH21413: COV002)

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant (STH21413: COV002)

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera (STH21413: COV002)

Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses (STH21413: COV002)

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK (STH21413: COV002)

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial (STH21413: COV002)

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial (STH21413: COV002)

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials (STH21413: COV002)

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial (STH21413: COV002)

Repeatability and sensitivity to change of noninvasive end points in PAH: the RESPIRE study (STH18285: REPEATABILITY)

Effect of denosumab on osteolytic lesion activity after total hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial (STH15714: Denosumab in THA)

Femoral neck strain prediction during level walking using a combined musculoskeletal and finite element model approach (STH19009: MultiSim Developing models of the human musculoskeletal system)

Fit for purpose? A cross-sectional study to evaluate the acceptability and usability of HeadUp, a novel neck support collar for neurological neck weakness (STH15573: Head Up)

Deficits in Mitochondrial Spare Respiratory Capacity Contribute to the Neuropsychological Changes of Alzheimer’s Disease (STH17001: Improving detection and prevention of cognitive decline in ageing)

Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study (STH17001: Improving detection and prevention of cognitive decline in ageing)

Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT (STH17249: MS-SMART)

Psychological and demographic characteristics of 368 patients with dissociative seizures: data from the CODES cohort (STH18295: CODES)

A Multifactorial Model of Multiple Sclerosis Gait and Its Changes Across Different Disability Levels (STH18829: MS SMART - ADD ON)

Wearable sensors can reliably quantify gait alterations associated with disability in people with progressive multiple sclerosis in a clinical setting (STH18829: MS SMART - ADD ON)

Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS (STH19145: SOD1)

Value of systematic genetic screening of patients with amyotrophic lateral sclerosis (STH19219: AMBRoSIA)

Caregiver Delivered Sensory Electrical Stimulation for Post Stroke Upper Limb Spasticity: A Single Blind Crossover Randomized Feasibility Study (STH19263: MUSTS)

Ofatumumab versus Teriflunomide in Multiple Sclerosis (STH19613: Asclepios)

Value of cervical electrical impedance spectroscopy to predict spontaneous preterm delivery in asymptomatic women: the ECCLIPPx prospective cohort study (STH16102: ECCLIPPX-spectroscopy of the cervix)

Is short-term-variation of fetal-heart-rate a better predictor of fetal acidaemia in labour? A feasibility study (STH19362: STV Monica Study)

Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study (STH21366: UKOSS PIP)

Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension (STH15222: STH-ObS)

Long-term study of oral treprostinil to treat pulmonary arterial hypertension: dosing, tolerability, and pharmacokinetics (STH15554: freedom-C, STH15578: freedom-C)

Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome (STH17049: UK-HIPAH)

Bayesian Inference Associates Rare KDR Variants With Specific Phenotypes in Pulmonary Arterial Hypertension (STH17067: BRIDGE & STH17049: UK-HIPAH)

Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension (STH17067: BRIDGE & STH17049: UK-HIPAH)

Results from the REPAIR Study Final Analysis: Effects of Macitentan on Right Ventricular (RV) Remodelling in Pulmonary Arterial Hypertension (PAH) (STH18766: REPAIR)

Direct healthcare resource utilisation, health-related quality of life, and work productivity in patients with moderate rheumatoid arthritis: an observational study (STH20702: RAUNMET)

Outcomes in rheumatoid arthritis patients treated with abatacept: a UK multi-centre observational study (STH20867: Observational chart review study of patients with rheumatoid arthritis treated with abatacept.)

Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial (STH18657: Vaccination in prostate caNCEr - VANCE01)

Radical Cystectomy Against Intravesical BCG for High-Risk High-Grade Nonmuscle Invasive Bladder Cancer: Results From the Randomized Controlled BRAVO-Feasibility Study (STH19168: BRAVO study 2: RCT)