NIHR Clinical Research Facility: Sheffield

Providing excellence in clinical research delivery

The National Institute for Health and Care Research (NIHR) Clinical Research Facility (CRF): Sheffield is part of the NIHR and hosted by Sheffield Teaching Hospitals NHS Foundation Trust in partnership with the University of Sheffield.

The NIHR funds, enables and delivers world-leading health and social care research that improves people’s health and wellbeing and promotes economic growth.

NIHR Clinical Research Facilities (CRFs) are purpose-built facilities in NHS hospitals where researchers can conduct studies. The NIHR has awarded £161 million over 5 years to 28 CRF facilities across England, to support early-phase and complex studies.

In 2022, the NIHR CRF: Sheffield was awarded £7.9m in funding which will support the development and testing of new treatments for diseases, many of which currently have no cure. This funding award covers 2022 to 2029.

Read more about the NIHR CRF: Sheffield and the work we do

The NIHR is 20!

It's the NIHR's 20th anniversary! Since 2006 the NIHR has been driving life-changing research for the health and wealth of the nation - funded by the public, for the public.

For NIHR20, we are celebrating the impact we have made. We will be marking some of our most significant past achievements, reflecting on shared successes with our partners and extraordinary research community, and looking forward to the future.

For more details see the NIHR website.

Key Statistics

News & events

Pioneering CAR T-cell therapy for MS research features on BBC Look North

Sheffield's role in pioneering CAR T therapy as a potential treatment for multiple sclerosis (MS) has featured on BBC Look North.

The piece, which aired on Monday 3 August and was filmed at the NIHR Clinical Research Facility: Sheffield, featured interviews with Professor Basil Sharrack and Professor John Snowden.

The BBC also interviewed first Sheffield trial participant Numan Unees, who was diagnosed with MS six years ago and was left unable to walk unaided.

The 40-year-old, from Rotherham, was the first person in Sheffield and the seventh in a global trial to receive CAR T-cell therapy as a potential treatment for MS.

The trial, known as AUTOMS-1 or BOBCAT, is assessing if CAR T cell therapy, which was originally developed to treat some cancers, could be a potential treatment for MS.

(August 2026)