2023/24 Publications

Between 1st April 2023 - 31st March 2024, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).

Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial (STH19901: CRYOSTAT2)

Prehospital early warning scores for adults with suspected sepsis: retrospective diagnostic cohort study (STH20280: PHEWS)

Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial (STH20728: UK-REBOA)

Efficacy and safety of hybrid epicardial and endocardial ablation versus endocardial ablation in patients with persistent and longstanding persistent atrial fibrillation: a randomised, controlled trial (STH19031: CEASE AF)

Pulmonary Hypertension: Intensification and Personalization of Combination Rx (PHoenix): A phase IV randomized trial for the evaluation of dose‐response and clinical efficacy of riociguat and selexipag using implanted technologies (STH21653: PHoenix)

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 (STH21104: GenOMICC)

Quality of recovery following childbirth: a prospective, multicentre cohort study (STH21138: ObsQoR)

A randomized, double-blind, placebo-controlled phase 2 study of intratympanic OTO-313 in patients with moderate to severe subjective tinnitus (STH21863: OTONOMY OTO)

Can an educational video improve the adequacy of bowel preparation for patients undergoing their first colonoscopy? Results of the EBOPS RCT (STH20459: EBOP)

Simple versus Radical Hysterectomy in Women with Low-Risk Cervical Cancer (STH18293: SHAPE)

Clinical effectiveness of vaginal pessary self-management vs clinic-based care for pelvic organ prolapse (TOPSY): a randomised controlled superiority trial (STH20486: TOPSY)

Parsaclisib, a PI3Kδ inhibitor, in relapsed and refractory follicular lymphoma (CITADEL-203): a phase 2 study (STH20540: CITADEL-203)

Parsaclisib, a PI3Kδ inhibitor, in relapsed and refractory mantle cell lymphoma (CITADEL-205): a phase 2 study (STH20589: CITADEL-205)

Phase 3 Trial of Concizumab in Hemophilia with Inhibitors (STH21015: Explorer 7)

SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease (STH21731: OCTAVE)

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study (STH16263: HCV Research UK V1)

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization (STH21439: PHOSP-COVID)

Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls (STH21439: PHOSP-COVID)

Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury (STH21439: PHOSP-COVID)

Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis (STH21439: PHOSP-COVID)

Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study – A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines (STH21800: COM-COV2)

Immunogenicity and safety of AZD2816, a beta (B.1.351) variant COVID-19 vaccine, and AZD1222 (ChAdOx1 nCoV-19) as third-dose boosters for previously vaccinated adults: a multicentre, randomised, partly double-blinded, phase 2/3 non-inferiority immunobridging study in the UK and Poland (STH21874: The AZ Variant Study)

Omicron BA.1-containing mRNA-1273 boosters compared with the original COVID-19 vaccine in the UK: a randomised, observer-blind, active-controlled trial (STH22175: MODERNA BOOSTER)

Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen (STH19197: Baby-OSCAR)

A Double-Blind, Randomized, Placebo-Controlled Trial of Ursodeoxycholic Acid (UDCA) in Parkinson's Disease (STH18493: UP Study)

Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial (STH19688: IONIS)

Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study (STH21068: Raise & STH21113: Raise XT)

Interim phase 1 part A results for ALN-APP, the first investigational RNAi therapeutic in development for Alzheimer’s disease (STH22052: ALN-APP-001)

Catheter event rates in medical compared to surgical peritoneal dialysis catheter insertion (STH18334: UKPDOPPS 2)

Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial (STH19730: BISTRO)

Unsupervised machine learning to investigate trajectory patterns of COVID-19 symptoms and physical activity measured via the MyHeart Counts App and smart devices (STH15222: CVRU Tissue Bank)

Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension (STH17049: PAH COHORT)

Comparison of cardiac magnetic resonance imaging, functional and haemodynamic variables in pulmonary arterial hypertension: insights from REPAIR (STH18766: REPAIR)

Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis Trial—MIST-3 (STH19589: MIST3)

PET-CT-guided versus CT-guided biopsy in suspected malignant pleural thickening: a randomised trial (STH19648: TARGET)

Reflecting real-world patients with mesothelioma in research: an interim report of baseline characteristics from the ASSESS-meso cohort (STH20915: ASSESS-meso)

Early infection risk in patients with systemic lupus erythematosus treated with rituximab or belimumab from the British Isles Lupus Assessment Group Biologics Register (BILAG-BR): a prospective longitudinal study (STH15729: BILAG BR)

Comparative Effectiveness, Time to Discontinuation, and Patient-Reported Outcomes with Baricitinib in Rheumatoid Arthritis: 2-Year Data from the Multinational, Prospective Observational RA-BE-REAL Study in European Patients (STH20530: RA-BE-REAL)

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (STH22308: Monitoring of inflammatory conditions)

A vein bypass first versus a best endovascular treatment first revascularisation strategy for patients with chronic limb threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal revascularisation procedure to restore limb perfusion (BASIL-2): an open-label, randomised, multicentre, phase 3 trial (STH18431: BASIL-2)