2018/19 Publications
Between 1st April 2018 - 31st March 2019, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).
Accident & Emergency
Understanding the management of patients with head injury taking warfarin: who should we scan and when? Lessons from the AHEAD study (15705: The AHEAD Study)
Consensus-derived clinical decision rules to guide advanced imaging decisions for pulmonary embolism in pregnancy and the postpartum period (STH17334: DiPEP)
Selecting pregnant or postpartum women with suspected pulmonary embolism for diagnostic imaging: the DiPEP diagnostic study with decision-analysis modelling (STH17334: DiPEP)
Cardiovascular
Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation (STH15268: The Amaze Trial)
Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction: ATLANTIC-Morphine (STH16126: The ATLANTIC Study)
Pre-hospital administration of ticagrelor in diabetic patients with ST-elevation myocardial infarction undergoing primary angioplasty: A sub-analysis of the ATLANTIC trial (STH16126: The ATLANTIC Study)
Study of Two Dose Regimens of Ticagrelor Compared with Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention for Stable Coronary Artery Disease (STEEL-PCI) (STH18423: STEEL PCI)
Very-low-dose twice-daily aspirin maintains platelet inhibition and improves haemostasis during dual-antiplatelet therapy for acute coronary syndrome (STH19177: WILLOW - ACS)
Pharmacodynamic Effects of a 6-Hour Regimen of Enoxaparin in Patients Undergoing Primary Percutaneous Coronary Intervention (PENNY PCI Study) (19752: PENNY PCI)
Dermatology
Allergy Alert Test for p-Phenylenediamine-Allergic Hair Dye Users (STH16486: Proof of Concept Allergy Alert Test)
Diabetes & Endocrinology
A prospective longitudinal study of Pasireotide in Nelson's syndrome (STH15164: SOM230 in Nelson's Syndrome)
Sustained Reduction in Severe Hypoglycemia in Adults With Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia: Two-Year Follow-up in the HypoCOMPaSS Randomized Clinical Trial (15582: HYPOCOMPASS)
Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans (18300: Hypoglycaemia)
Prolonged Prothrombotic Effects of Antecedent Hypoglycemia in Individuals With Type 2 Diabetes (18300: Hypoglycaemia)
Multicentre, double-blind, crossover trial to identify the Optimal Pathway for TreatIng neurOpathic paiN in Diabetes Mellitus (OPTION-DM): study protocol for a randomised controlled trial. (STH18976: OPTION-DM)
Salbutamol‐induced electrophysiological changes show no correlation with electrophysiological changes during hyperinsulinaemic–hypoglycaemic clamp in young people with Type 1 diabetes (STH20048: Impaired Awareness of Hypoglycemia (IAH))
Gastroenterology
Haematology
Infectious Diseases
HIV gp120 in the Lungs of Antiretroviral Therapy-treated Individuals Impairs Alveolar Macrophage Responses to Pneumococci (STH15411: HIV in S. pneumoniae infection)
Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists (STH15949: Bacterial colonisation in COPD)
Medical Imaging & Medical Physics
Diagnosis of Pulmonary Hypertension with Cardiac MRI: Derivation and Validation of Regression Models (STH18285: REPEATABILITY)
Metabolic Bone
The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA? (STH15691: Sheffield Musculoskeletal Biobank)
Neonatology
Neurological
Efficacy of the Head Up collar in facilitating functional head movements in patients with Amyotrophic Lateral Sclerosis (STH15573: Head Up)
Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study (STH17249: MS-SMART)
Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease (STH18493: UP study)
A thorough characterisation of gait impairment in patients with Multiple Sclerosis (STH18829: MS SMART - ADD ON)
Reduced habit-driven errors in Parkinson’s Disease (STH20087: ATP correlation in PD)
Obstetrics
Mid-gestational changes in cervicovaginal fluid cytokine levels in asymptomatic pregnant women are predictive markers of inflammation-associated spontaneous preterm birth (STH16102: ECCLIPPX)
Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: Results from the MAVIDOS trial (15780: MAVIDOS)
Renal
Mortality risk in patients on hemodiafiltration versus hemodialysis: a 'real-world' comparison from the DOPPS (STH14183: DOPPS)
Diagnostic Accuracy of Biomarkers and Imaging for Bone Turnover in Renal Osteodystrophy (STH17141: Biomarkers and imaging techniques)
Intravenous Iron in Patients Undergoing Maintenance Hemodialysis (STH18111: PIVOTAL)
Effects of Sacubitril/Valsartan Versus Irbesartan in Patients with Chronic Kidney Disease: A Randomised Double-Blind Trial (STH18238: UK Heart and Renal Protection (HARP)-III)
Respiratory
Divergent Roles for TRAIL in Lung Diseases (STH16436: PAH Biobank)
Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis (STH18400: Bridge)
Identification of rare sequence variation underlying heritable pulmonary arterial hypertension (STH18400: Bridge)
Rheumatology
Recurrent serious infections in patients with rheumatoid arthritis-results from the British Society for Rheumatology Biologics Register (STH14349: BSRBR-RA)
The effects of upper and lower limb exercise on the microvascular reactivity in limited cutaneous systemic sclerosis patients (STH19339 Exercise in patients with Systemic Sclerosis)