2019/20 Publications
Between 1st April 2019 - 31st March 2020, the following articles were published by researchers using the NIHR Sheffield Clinical Research Facility (CRF).
Accident & Emergency
Cardiovascular
Clinical impact and predictors of complete ST segment resolution after primary percutaneous coronary intervention: A subanalysis of the ATLANTIC Trial (STH16126: ATLANTIC)
Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes (STH20030: A multi-center, double-blind, randomized, placebo-controlled study to assess the pharmacodynamics, pharmacokinetics, tolerability, and safety of a single subcutaneous injection of ACT-246475 in adults with stable coronary artery disease)
Dermatology
Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2 (STH18454: Liberty AD SOLO)
Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial (STH18627: BEEP)
Haematology
Infectious Diseases
ART in HIV-Positive Persons With Low Pretreatment Viremia: Results From the START Trial (STH15942: START)
Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison (STH15942: START)
Risk factors for antiretroviral therapy (ART) discontinuation in a large multinational trial of early ART initiators (STH15942: START)
Role of Inflammatory Biomarkers in the Prevalence and Incidence of Hypertension Among HIV-Positive Participants in the START Trial (STH15942: START)
The benefit of immediate compared with deferred antiretroviral therapy on CD4+ cell count recovery in early HIV infection (STH15942: START)
Neurological
Serum FGF-21, GDF-15, and blood mtDNA copy number are not biomarkers of Parkinson disease (STH16350: Mitochondrial biomarkers in Parkinson’s)
Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in Alzheimer's disease (STH17001: Improving detection and prevention of cognitive decline in ageing)
Using telehealth in motor neuron disease to increase access to specialist multidisciplinary care: a UK-based pilot and feasibility study (STH17165: Telehealth in Motor Neurone Disease)
Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2) (STH18323: PISCES II)
Transcutaneous Auricular Vagus Nerve Stimulation with Upper Limb Repetitive Task Practice May Improve Sensory Recovery in Chronic Stroke (STH19008: Feasibility and Acceptability of Transcutaneous Vagal Nerve Stimulation in Recovery of Upper Limb function Post Stroke)
Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial (STH19012: LEVALS DEME4308)
Obstetrics
Postnatal pelvic floor muscle stiffness measured by vaginal elastometry in women with obstetric anal sphincter injury: a pilot study (STH18128: Pelvic floor dysfunction)
Orthopaedics
Renal Services
Retraining for prevention of peritonitis in peritoneal dialysis patients: A randomized controlled trial (STH16431: Peritonitis Prevention Study (PEPS))
Respiratory
Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension (STH17049: PAH COHORT)
Germline selection shapes human mitochondrial DNA diversity (STH18400: NIHR BioResource Rare Diseases)