NIHR Clinical Research Facility: Sheffield

Between 1 April 2021 and 31 March 2022, the following articles were published which relate to studies that have been supported by the NIHR Clinical Research Facility (CRF): Sheffield.

Do not attempt cardiopulmonary resuscitation (DNACPR) decisions in people admitted with suspected COVID-19: Secondary analysis of the PRIEST observational cohort study (STH16228: PRIEST)

Prognostic accuracy of emergency department triage tools for adults with suspected COVID-19: the PRIEST observational cohort study (STH16228: PRIEST)

Prognostic accuracy of triage tools for adults with suspected COVID-19 in a prehospital setting: an observational cohort study (STH16228: PRIEST)

Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial (STH18377: RAPID CTCA)

A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach (STH15222: CVRU Tissue Bank)

Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood (STH15222: CVRU Tissue Bank)

Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the PKC inhibitor ruboxistaurin (STH15222: CVRU Tissue Bank, STH21671: COVID-INNATE)

Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: machine learning on proteomics from the DETECT cohort (STH15222: CVRU Tissue Bank)

Complete Revascularization in Patients Undergoing a Pharmacoinvasive Strategy for ST-Segment–Elevation Myocardial Infarction: Insights From the COMPLETE Trial (STH18050: COMPLETE)

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study (STH18220: ISARIC)

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke (STH19092: LAAOS III)

Contribution of NOTCH1 genetic variants to bicuspid aortic valve and other congenital lesions (STH19626: BRAVE)

Left ventricular blood flow kinetic energy is associated with the six-minute walk test and left ventricular remodelling post valvular intervention in aortic stenosis (STH19627: EurValve)

Mitral regurgitation quantification by cardiac magnetic resonance imaging (MRI) remains reproducible between software solutions (STH19627: EurValve)

Bentracimab for Ticagrelor Reversal in Patients Undergoing Urgent Surgery (STH21523: PB2452 - REVERSE-IT TRIAL)

A prenylated dsRNA sensor protects against severe COVID-19 (STH18220: ISARIC)

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK (STH18220: ISARIC)

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study (STH18220: ISARIC)

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study (STH18220: ISARIC)

Importance of patient bed pathways and length of stay differences in predicting COVID-19 hospital bed occupancy in England (STH18220: ISARIC)

Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial (STH19522: RePHILL)

A common TMPRSS2 variant has a protective effect against severe COVID-19 (STH21104: GenOMICC)

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19 (STH21104: GenOMICC)

Two Key Takeaways From a Year of Pandemic Research (STH21104: GenOMICC & STH21369: REMAP-CAP)

Whole genome sequencing reveals host factors underlying critical Covid-19 (STH21104: GenOMICC)

Effect of Convalescent Plasma on Organ Support–Free Days in Critically Ill Patients With COVID-19 - A Randomized Clinical Trial (STH21369: REMAP-CAP)

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial (STH21369: REMAP-CAP)

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials (STH21369: REMAP-CAP)

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 (STH21369: REMAP-CAP)

Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom: Interactions of Viral Load, Antibody Status, and B.1.1.7 Infection (STH21369: REMAP-CAP)

Dupilumab Significantly Modulates Pain and Discomfort in Patients With Atopic Dermatitis: A Post Hoc Analysis of 5 Randomized Clinical Trials (STH18454: REGENERON, STH18863: SOLO Continue, STH19126: Phase 3 Study Investigating the Efficacy, Safety and Tolerability of Dupilumab Monotherapy Administered to Adult Patients With Atopic Dermatitis (AD) Who Are Not Adequately Controlled With or Are Intolerant to Oral Cyclosporine or When This Treatment is Not Medically Advisable.)

Impact of oral abrocitinib on signs, symptoms and quality of life among adolescents with moderate-to-severe atopic dermatitis: an analysis of patient-reported outcomes (STH20279: JADE,  STH20660: JADE Extension)

An oral lipidic native testosterone formulation that is absorbed independent of food (STH18456: DITEST-001)

Adjuvant Rituximab—Exploratory Trial in Young People With Graves Disease (STH18687: RiGD)

Vitamin D supplementation in people with IBS has no effect on symptom severity and quality of life: results of a randomised controlled trial (90060: Vitamin D and IBS)

Endometrial scratch to increase live birth rates in women undergoing first-time in vitro fertilisation: RCT and systematic review (STH18142: endometrial scratch)

Experiences of trial participants and site staff of participating in and running a large randomised trial within fertility (the endometrial scratch trial): a qualitative interview study (STH18142: endometrial scratch)

Post-hoc analysis on the long-term response to fixed-dose prophylaxis with N8-GP in patients with haemophilia A (STH16367: Pathfinder 2)

Turoctocog alfa pegol (N8-GP) in severe hemophilia A: Long-term safety and efficacy in previously treated patients of all ages in the pathfinder8 study (STH20340: Pathfinder 8)

Sero-reactivity to three distinct regions within the hepatitis C virus alternative reading frame protein (ARFP/core+1) in patients with chronic HCV genotype-3 infection (STH16263: HCV Research UK V1)

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial (STH21355: RECOVERY)

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial (STH21355: RECOVERY)

Two Key Takeaways From a Year of Pandemic Research (STH21355: RECOVERY)

Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves (STH21374: COG-UK HOCI)

Post-Vaccination Coronavirus Disease 2019: A Case-Control Study and Genomic Analysis of 119 Breakthrough Infections in Partially Vaccinated Individuals (STH21374: COG-UK HOCI)

SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort study (STH21374: COG-UK HOCI)

The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study (STH21374: COG-UK HOCI)

AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific TH1 response with a diverse TCR repertoire (STH21413: COV-002)

Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection (STH21413: COV-002)

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002) (STH21413: COV-002)

Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera (STH21413: COV-002)

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum (STH21413: COV-002)

Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial (STH21413: COV-002)

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses (STH21413: COV-002)

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study (STH21439: PHOSP-COVID)

COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study (STH21461: SIREN)

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine (STH21461: SIREN & STH21520: PITCH)

Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection (STH21461: SIREN)

SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN) (STH21461: SIREN)

Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial (STH21467: CATALYST)

T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study (STH21520: PITCH)

Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial (STH21800: COM-COV2)

Use of Procalcitonin during the First Wave of COVID-19 in the Acute NHS Hospitals: A Retrospective Observational Study (STH21501: PEACH)

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations (STH15691: Sheffield Musculoskeletal Biobank)

Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis (STH15691: Sheffield Musculoskeletal Biobank)

Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia (STH18213: The Stag Study)

Fatigue and anxiety mediate the effect of dyspnea on quality of life in amyotrophic lateral sclerosis (STH16508: TONIC)

Cognitive–behavioural therapy compared with standardised medical care for adults with dissociative non-epileptic seizures: the CODES RCT (STH18295: CODES)

Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts (STH19219: AMBRoSIA)

Proteomic Approaches to Study Cysteine Oxidation: Applications in Neurodegenerative Diseases (STH19219: AMBRoSIA & STH19982: COeN)

The application of Raman spectroscopy to the diagnosis of mitochondrial muscle disease: A preliminary comparison between fibre optic probe and microscope formats (STH19266: Raman)

New autoimmune diseases after autologous hematopoietic stem cell transplantation for multiple sclerosis (STH19379: STAR MS)

Results of the first-in-human, randomized, double-blind, placebo-controlled phase 1b study of lumbar intrathecal bolus administrations of antisense oligonucleotide (ISIS 814907; BIIB080) targeting tau mRNA in patients with mild Alzheimer’s disease (STH19688: IONIS)

Assessment of the Precision in Measuring Glutathione at 3 T With a MEGA-PRESS Sequence in Primary Motor Cortex and Occipital Cortex (STH19982: COeN)

Correlations between measures of ALS respiratory function: is there an alternative to FVC? (STH20135: TRICALS)

Vagus Nerve Stimulation for Upper Limb Function (STH20221: VNS-REHAB)

Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial (STH20221: VNS-REHAB)

Transcutaneous vagus nerve stimulation (tVNS) in stroke: the evidence, challenges and future directions (STH21409: tVNS)

The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS) (STH21366: UKOSS PIP)

The Effects of Type 1 Diabetes and Diabetic Peripheral Neuropathy on the Musculoskeletal System: A Case–Control Study (STH19719: An evaluation of bone microarchitecture)

Use of cast immobilisation versus removable brace in adults with an ankle fracture: multicentre randomised controlled trial (STH20049: AIR)

Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood (STH17049: PAH COHORT)

Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH (STH18400: Bridge)

Mendelian randomisation and experimental medicine approaches to IL-6 as a drug target in PAH (STH19081: TRANSFORM-UK)