2022/23 publications

Between 1 April 2022 and 31 March 2023, the following articles were published which relate to studies that have been supported by the NIHR Sheffield Clinical Research Facility (CRF).

Accuracy of emergency medical service telephone triage of need for an ambulance response in suspected COVID-19: an observational cohort study (STH16228: PRIEST)

Presentation cardiac troponin and early computed tomography coronary angiography in patients with suspected acute coronary syndrome: a pre-specified secondary analysis of the RAPID-CTCA trial (STH18377: RAPID CTCA)

Influence of body weight and body mass index on the chronic pharmacokinetic and pharmacodynamic responses to clinically available doses of ticagrelor in patients with chronic coronary syndromes (STH15908: PEGASUS)

Lipoprotein(a), cardiovascular events, and benefit of P2Y12 inhibition: insights from the PEGASUS-TIMI 54 trial (STH15908: PEGASUS)

Patient selection for long-term secondary prevention with ticagrelor: insights from PEGASUS-TIMI 54 (STH15908: PEGASUS)

Complete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction. Results From the COMPLETE Randomized Clinical Trial (STH18050: COMPLETE)

TCT-36 Complete Revascularization Versus Culprit Lesion–Only PCI in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease: A Subgroup Analysis of the COMPLETE Trial (STH18050: COMPLETE)

Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial (STH19388: IRONMAN)

Routine Pressure Wire Assessment Versus Conventional Angiography in the Management of Patients With Coronary Artery Disease: The RIPCORD 2 Trial (STH19671: RIPCORD2)

Multicenter Randomized Trial of Intermittently Scanned Continuous Glucose Monitoring Versus Self-Monitoring of Blood Glucose in Individuals With Type 2 Diabetes and Recent-Onset Acute Myocardial Infarction: Results of the LIBERATES Trial (STH19837: LIBERATES)

Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry (STH21180: NSTEMI Registry)

Presentation, care, and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology (STH21180: NSTEMI Registry)

Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice (STH21919: ALABAMA)

Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study (STH18220: ISARIC)

Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study (STH18220: ISARIC)

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (STH18220: ISARIC)

Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial (STH18976: OPTION-DM)

Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT (STH18976: OPTION-DM)

Who really benefits from drug combinations and long titrations for pain? – Authors' reply (STH18976: OPTION-DM)

A randomised, double-blind, placebo-controlled, multicentre clinical trial of AZD1656 in diabetic patients hospitalised with COVID-19: The ARCADIA Trial - implications for therapeutic immune modulation (STH21519: ARCADIA)

Endometrial scratch in women undergoing first-time IVF treatment: a systematic review and meta-analysis of randomized controlled trials (STH18142: endometrial scratch)

Shared decision-making during  childbirth in maternity units: the VIP mixed-methods study (STH18641: VIP)

A pilot study to evaluate changes in pelvic floor muscle tone following pelvic organ prolapse surgery using a novel intra-vaginal pressure sensor device (STH20182: IVPSD)

Long-term efficacy and safety of subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors (STH19995: Explorer 4)

Fixed-Duration Ibrutinib-Venetoclax in Patients with Chronic Lymphocytic Leukemia and Comorbidities (STH20256: GLOW)

Phase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B (STH20490: B-AMAZE)

Efficacy and Safety of Single-Agent Zandelisib Administered By Intermittent Dosing in Patients with Relapsed or Refractory (R/R) Follicular Lymphoma (FL): Final Results of the Tidal Phase 2 Study (20634: TIDAL Study - ME-401)

Clonal population expansion of Staphylococcus aureus occurs due to escape from a finite number of intraphagocyte niches (STH14625: Macrophage responses to micro-organisms)

A randomized phase 3 trial of the immunogenicity and safety of coadministration of a live-attenuated tetravalent dengue vaccine (TAK-003) and an inactivated hepatitis a (HAV) virus vaccine in a dengue non-endemic country (STH20140: DEN 314)

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis (STH21355: RECOVERY)

Factors affecting turnaround time of SARS-CoV-2 sequencing for inpatient infection prevention and control decision making: analysis of data from the COG-UK HOCI study (STH21374: COG-UK HOCI)

An exploratory analysis of the response to ChAdOx1 nCoV-19 (AZD1222) vaccine in males and females (STH21413: COV002)

Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19 (STH21439: PHOSP-COVID)

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study (STH21439: PHOSP-COVID)

Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study (STH21439: PHOSP-COVID)

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study (STH21439: PHOSP-COVID)

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination (STH21439: PHOSP-COVID)

Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens (STH21520: PITCH)

A plain language summary of the Janssen COVID-19 vaccine effectiveness and safety as a single dose and with a booster (STH21570: ENSEMBLE-2)

Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial (STH21570: ENSEMBLE-2)

Semi-automatic thresholding of RV trabeculation improves repeatability and diagnostic value in suspected pulmonary hypertension (STH18285: REPEATABILITY)

Validation of Artificial Intelligence Cardiac MRI Measurements: Relationship to Heart Catheterization and Mortality Prediction (STH18285: REPEATABILITY)

The Kinesin Gene KIF26B Modulates the Severity of Post-Traumatic Heterotopic Ossification (STH15691: Sheffield Musculoskeletal Biobank)

Parent–infant closeness after preterm birth and depressive symptoms: A longitudinal study (STH20211: Closeness)

Prevalence of depression in amyotrophic lateral sclerosis/motor neuron disease: multi-attribute ascertainment and trajectories over 30 months (STH16508:TONIC)

Autologous haematopoietic stem cell transplantation for immune-mediated neurological diseases: what, how, who and why? (STH16542: MIST)

Moderators of cognitive behavioural therapy treatment effects and predictors of outcome in the CODES randomised controlled trial for adults with dissociative seizures (STH18295: CODES)

Performance of the GAD-7 in adults with dissociative seizures (STH18295: CODES)

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS (STH19145: SOD1)

Rapid identification of human muscle disease with fibre optic Raman spectroscopy (STH19266: Raman)

Key demographics and psychological skills associated with adjustment to progressive Multiple Sclerosis early in the diagnosis (STH19549: Psychological Adjustment in Progressive Multiple Sclerosis (PAIPMS))

Non-negative matrix factorisation of Raman spectra finds common patterns relating to neuromuscular disease across differing equipment configurations, preclinical models and human tissue (STH19904: Novel electrical impedance spectroscopy for neurological disorders.)

Fatigue in multiple sclerosis: A UK MS-register based study (STH19939: MS Register)

Vagus nerve stimulation paired with rehabilitation for stroke: Implantation experience from the VNS-REHAB trial (STH20221: VNS-REHAB)

Vagus Nerve Stimulation Paired With Rehabilitation for Upper Limb Motor Impairment and Function After Chronic Ischemic Stroke: Subgroup Analysis of the Randomized, Blinded, Pivotal, VNS-REHAB Device Trial (STH20221: VNS-REHAB)

RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer’s Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity (STH20325: Infection & Dementia)

Comparison of switching to 6-week dosing of natalizumab versus continuing with 4-week dosing in patients with relapsing-remitting multiple sclerosis (NOVA): a randomised, controlled, open-label, phase 3b trial (STH20709: NOVA)

Exploratory clinical efficacy and patient-reported outcomes from NOVA: A randomized controlled study of intravenous natalizumab 6-week dosing versus continued 4-week dosing for relapsing-remitting multiple sclerosis (STH20709: NOVA)

The acceptability of cervical electrical impedance spectroscopy within a multi-modal preterm birth screening package: a mixed methods study (STH16102: ECCLIPPX)

Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease (STH18263: STOP-ACEi)

Variation in Peritoneal Dialysis Time on Therapy by Country Results from the Peritoneal Dialysis Outcomes and Practice Patterns Study (STH18334: UK PDOPPS)

The STAGED-PKD 2-Stage Adaptive Study With a Patient Enrichment Strategy and Treatment Effect Modeling for Improved Study Design Efficiency in Patients With ADPKD (STH20441: Staged-PKD (ADPKD))

Imaging biomarkers of lung ventilation in interstitial lung disease from 129Xe and oxygen enhanced 1H MRI (STH19593: TRISTAN)

A randomised controlled trial of intrapleural balloon intercostal chest drains to prevent drain displacement (STH20726: BASIC)

Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial (STH21421: STOP-COVID19)

Comorbidities in the UK Primary Sjögren’s Syndrome Registry (STH15541: UKPSSR)

Successful stopping of biologic therapy for remission in children and young people with juvenile idiopathic arthritis (STH17340: BCRD & STH18373: BSPAR)

Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial (STH19485: RECITAL)

The RA-BE-REAL Multinational, Prospective, Observational Study in Patients with Rheumatoid Arthritis Receiving Baricitinib, Targeted Synthetic, or Biologic Disease-Modifying Therapies: a 6-Month Interim Analysis (STH20530: RA-BE-REAL)